Primary Hyperparathyroidism Associated with Papillary Thyroid Carcinoma
Keywords:
primary hyperparathyroidism; parathyroidectomy; papillary thyroid cancerAbstract
Introduction: Primary hyperparathyroidism is caused by excessive secretion of parathyroid hormone by one or more parathyroid glands. Solitary parathyroid adenoma is the cause in approximately 80% of patients, with the remainder mainly due to multiple adenomas, hyperplasia, and, rarely, carcinomas.
Objective: To present the case of a male patient affected by primary hyperparathyroidism associated with papillary thyroid carcinoma.
Case presentation: We present the case of a 22-year-old male patient with elevated serum calcium and parathyroid hormone levels and decreased serum phosphorus, associated with osteolytic manifestations. As this is a rare combination of conditions, it is considered of scientific interest to publish the case for the benefit of professionals involved in the study and treatment of surgical conditions of the neck.
Conclusions: The classic and symptomatic form of hyperparathyroidism in young male patients with concomitant papillary thyroid carcinoma is uncommon. In these cases, the combination of surgical techniques for resection of both glands is justified.
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1. Ortiz C. El último descubrimiento anatómico: las glándulas paratiroides o Glandulae parathyreoideae de Owen-Sandström-Gley. Cir Cir. 2022 [acceso 30/07/2024];90(1):140-9. Disponible en: https://www.cirugiaycirujanos.com/files/circir_22_90_1_140-149.pdf
2. Olguín JS, Arias A, Garzón A, Peretti E, Guzmán L, Ruggieri M. Risk factors for surgical failure in patients undergoing surgery for primary hyperparathyroidism. Cir Esp (English Edition). 2022 [acceso 30/07/2024];100(9):569-72. Disponible en: https://app.dimensions.ai/details/publication/pub.1147505944
3. Oner M, Hacim NA. Is confirmation of parathyroid tissue section superior to localization of solitary parathyroid adenoma using intraoperative gamma probe survey? A retrospective cohort study. Acta Endocrinol (Buchar). 2022 [acceso 30/07/2024];18(4):452-7. DOI: http://doi.org/10.4183/aeb.2022.452
4. Bollerslev J, Schalin JC, Rejnmark L, Siggelkow H, Morreau H, Thakker R, et al. Unmet therapeutic, educational and scientific needs in parathyroid disorders: Consensus Statement from the first European Society of Endocrinology Workshop (PARAT). Eur J Endocrinol. 2019 [acceso 30/07/2024];181(3):P1-19. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598862
5. Amaral S, Rego T, Palha A, Carrilho N, Coutinho JM, Tavares P, et al. Preoperative Location Of Parathyroid Adenomas In Primary Hyperparathyroidism: The Role of Cervical Doppler Ultras. Acta Med Port. 2022 [acceso 30/07/2024];36(4):246-53. Disponible en: https://actamedicaportuguesa.com/revista/index.php/amp/ article/download/18735/14979
6. Marx SJ. Hyperparathyroid and hypoparathyroid disorders. N Engl J Med. 2000 Dec [acceso 30/07/2024];343(25):1863-75. Disponible en: https://pubmed.ncbi.nlm.nih.gov/11117980
7. Martínez RO, Cantú M, Marcos ER, Ceceñas LA, Treviño MA. Carcinoma paratiroideo tratado con paratiroidectomía más hemitiroidectomía. Cir Cir. 2020 [acceso 30/07/2024];88(91):1-4. Disponible en: https://www.cirugiaycirujanos.com/files/circir_20_88_supl_1_001-004.pdf
8. Montenegro I, Brochado AI, Branco I, Mateus S, Martins A. Rare Presentation of Primary Hyperparathyroidism in a Young Woman. Acta Médica Portuguesa. 2023 [acceso 30/07/2024];36(11):746-50. Disponible en: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/download/19616/15185
9. Rappoport D, Caballero MG, Cortés N, Cabané P, Gac P, Rodríguez F. Hiperparatiroidismo primario. Rev Cir. 2021;73(2):222-6. DOI: http://dx.doi.org/10.35687/s2452-45492021002910
10. Jackson CE, Norum RA, Boyd SB, Talpos GB, Wilson SD, Taggart RT, et al. Hereditary hyperparathyroidism and multiple ossifying jaw fibromas: a clinically and genetically distinct syndrome. Surgery. 1990 [acceso 30/07/2024];108(6):1006-12. Disponble en: https://pubmed.ncbi.nlm.nih.gov/2123361
11. Minisola S, Arnold A, Belaya Z, Brandi ML, Clarke BL, Hannan FM, et al. Epidemiology, Pathophysiology, and Genetics of Primary Hyperparathyroidism. J Bone Miner Res. 2022 [acceso 30/07/2024];37(11):2315-29. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10092691
12. Gheorghe AM, Sima OC, Florescu AF, Ciuche A, Nistor C, Sandru F, et al. Insights into Hyperparathyroidism-Jaw Tumour Syndrome: From Endocrine Acumen to the Spectrum of CDC73 Gene and Parafibromin-Deficient Tumours. Int J Mol Sci. 2024 [acceso 30/07/2024];25(4). Disponible en: https://pubmed.ncbi.nlm.nih.gov/38396977
13. Ovčariček PP, Giovanella L, Carrió GI, Hindié E, Huellner MW, Luster M, et al. The EANM practice guidelines for parathyroid imaging. Eur J Nucl Med Mol Imaging. 2021 [acceso 30/07/2024];48:2801-22. Disponible en: https://link.springer.com/content/pdf/10.1007/s00259-021-05334-y
14. Abd-Elhameed W, Ali RA. Efficacy of Scintigraphy, Ultrasound and Both Scintigraphy and Ultrasonography in Preoperative Detection and Localization of Primary Hyperparathyroidism. Cureus. 2019 [acceso 29/07/2024];11(6):e4960. Disponible en: https://assets.cureus.com/uploads/original_article/pdf/20453/ 1612428889-1612428884-20210204-18590-47zcux.pdf
15. Khokar AM, Kuchta KM, Moo-Young TA, Winchester DJ, Prinz RA. Increasing trend of bilateral neck exploration in primary hyperparathyroidism. Am J Surg. 2020 [acceso 28/07/2024];219(3):466-70. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31630823
16. Agirre L, de la Quintana A, Martínez G, Arana A, Servide MJ, Larrea J. Surgical results and the location of pathological glands in the treatment of primary sporadic hyperparathyroidism with negative preoperative 99mTc-sestamibi scintigraphy. Cir Esp. (English Edition). 2021 [acceso 30/07/2024];100(1):18-24. Disponible en: https://app.dimensions.ai/details/publication/pub.1143651920
17. Lanitis S, Chortis P, Sourtse G, Gkanis V, Lainas S, Tournis S, et al. Shifting from open to video-assisted parathyroidectomy: effect of the adjustment period on safety, clinical outcomes and cost. Ann R Coll Surg Engl. 2022;104(4):295-301. DOI: https://doi.org//10.1308/rcsann.2021.0162
18. González R F, Infante A, López MV, De Dios JM. Protocolo de diagnóstico y tratamiento del cáncer Tiroideo. Rev. Cubana Cir 2004 [acceso 17/02/2026];43(2).
Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-74932004000200001&lng=es
19. González R, Llapur A, Pérez D. Cirugía conservadora y tiroidectomía total en el cáncer tiroideo bien diferenciado. Rev. Cub. Cir. 2017 [acceso 02/11/2024];56(4). Disponible en: https://revcirugia.sld.cu/index.php/cir/article/view/618
20. González RF, Pavel I, Infante A, Domínguez C, López A. Cirugía Radioguiada en el tratamiento del hiperparatiroidismo primario. Rev. Cub. Cir. 2020 [acceso02/11/2024];59(3). Disponible en: https://revcirugia.sld.cu/index.php/cir/article/view/1008
21. González RF, Radioguided minimally invasive surgery in the treatment of primary hyperparathyroidism. IV World Surgeons Webinar 2023. Sun Text Reviews LLC, Arkansas 72712. United States; 2023 October 09-11 [acceso 07/02//2026]. Disponible en: https://suntexmeetings.com/surgeons
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