Behavior of Human Papillomavirus in Anal Cancer

Abstract

Introduction: In the late 1970s, the role of viruses in anal neoplasms began to be suspected; today, it is accepted that the onset of squamous cell carcinoma of the anus is associated with human papillomavirus infection.

Objective: To determine the behavior of high-risk human papillomavirus in anal cancer at the Comandante Manuel Fajardo University Surgical Hospital.

Methods: A prospective, descriptive, cross-sectional observational study was conducted between January 2018 and October 2020. The study population consisted of 24 patients. Theoretical and empirical research methods were used. The variables studied were sex and age, sexual preference, symptoms, risk factors, results of the clinical HPV study, and genotypes.

Results: 66.6% were female, with the 60-69 age group predominating for both sexes (37.5%). 62.5% tested positive for C-reactive protein in the blood. Genotype 18 was the most frequent (46.6%). Females were more likely to have a positive C-reactive protein level in the blood (66.7%). In males, the most frequent factor was toxic habits (33.3%), and in females, it was a personal history of cervical intraepithelial neoplasia caused by the human papillomavirus (53.3%).

Conclusions: Human papillomavirus is a precursor to anal cancer, and it is statistically

known that its morbidity has increased worldwide, making it necessary to understand

its behavior in the community served by the hospital.