Micronodular Thymoma with Lymphoid Stroma

Authors

Keywords:

mediastinal neoplasms; thymectomy; thymoma; epithelial tumor

Abstract

Introduction: Thymomas are epithelial tumors originating in the thymus gland, with an incidence of 0.13 cases per 100,000 inhabitants per year, and most commonly occurring between the ages of 40 and 60.

Objective: To present the main aspects of the treatment of a patient with micronodular thymoma at Dr. Miguel Enríquez University Hospital.

Case Presentation: A 46-year-old female patient with no significant past medical history reported weight loss, fatigue, and shortness of breath that had persisted for two weeks. She was initially diagnosed with Oropouche fever, but her clinical symptoms worsened without improvement, and she developed a cough with whitish sputum and retrosternal tightness; one month later, she underwent a chest X-ray and surgical evaluation. In the general surgery department, laboratory and imaging tests were ordered; a mediastinal tumor was suspected, and she underwent conventional thymectomy. The biopsy report confirmed the diagnosis of a thymoma.

Conclusions: The definitive diagnosis is generally established through postoperative histopathological examination; computed tomography (CT), with or without percutaneous biopsy, is the gold standard for preoperative diagnosis.

Downloads

Download data is not yet available.

Author Biographies

Armando Leal Mursulí, Hospital Universitario Dr. Miguel Enríquez. La Habana, Cuba.

Doctor en Ciencias Médicas. Máster en Urgencias Médicas. Profesor e Investigador Titular.Especialista de II Grado en Cirugía General y Oncológica. 

Yuleidy Feliq Díaz , Hospital Universitario Dr. Miguel Enríquez. La Habana, Cuba.

Profesor Auxiliar. Especialista de I Grado en Cirugía General. 

Yadira Anaya Mauri, Hospital Universitario Dr. Miguel Enríquez. La Habana, Cuba.

Asistente. Especialista de I Grado en Cirugía General. 

Raibel Kessell Maura, Hospital Clínico Quirúrgico Hermanos Ameijeiras. La Habana, Cuba.

Residente de 1er. año de Cirugía General.

References

1. Aguirre MA, Torres JA, Quito AX, Freire JA. Timoma, un tumor maligno poco frecuente con resolución quirúrgica mediante videotoracoscopia. Reporte de un caso. Rev Méd HJCA. 2022;14(1):45-9. DOI: http://dx.doi.or-g/10.14410/2022.14.1.cc.07

2. Hung CT, Tsai TF, Chen JS, Hsieh MS. Thymoma-associated multiorgan autoimmunity. BMJ Case Rep. 2019;12(8):e229163. DOI: https://doi.org/10.1136/bcr-2018-229163

3. Trujillo JC, Martínez E, Belda J. El timoma, ¿es una enfermedad sistémica? Arch Bronconeumol. 2019;55(5):235-236. DOI: https://doi.org/10.1016/j.arbres.2018. 03.014

4. Páramo AA, Lezama CA. Timoma: Experiencia y Resultados en un Centro de Tercer Nivel. Revista Científica y Académica. 2024;4(2):2452-63. DOI: http://dx.doi.org/10.61384/r.c.a..v4i2.385

5. Vicario AB, Espinosa- JF, Benítez. MDELP. La sinusitis que me salvó. Actualización en Medicina de Familia; 2024. DOI: http://dx.doi.org/10.55783/amf.s200202

6. Gerber TS, Strobl S, Marx A, Roth W, Porubsky S. Epidemiology of thymomas and thymic carcinomas in the United States and Germany, 1999-2019. Front Oncol 2023;13:1308989. DOI: http://dx.doi.org/10.3389/fonc.2023.1308989

7. Cabañas J, Román FJ, Thomas Á, Fagúndez FJ. Dolor torácico y fiebre. Hay vida más allá de la COVID-19. Rev clín med fam. 2021;14(2) DOI: http://dx.doi.org/10.55783/rcmf.140214

8.Valera M, Aldana J, Arrieta G, Arrieta M, Suárez- L. Timoma en paciente con COVID-19, hallazgo incidental: reporte de caso. Rev Cienc Biomed. 2024;13(1):37-43. DOI: http://dx.doi.org/10.32997/rcb-2024-4797

9. Guerrera F, Falcoz PE, Moser B, van Raemdonck D, Bille’ A, Toker A, et al. Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: a European Society of Thoracic Surgeons Thymic Working Group Study. Eur J Cardiothorac Surg. 2021;60(4):881-7. DOI: http://dx.doi.org/10.1093/ejcts/ezab224

10. Zhang Y, Lin D, Aramini B, Yang F, Chen X, Wang X, et al. Thymoma and thymic carcinoma: Surgical resection and multidisciplinary treatment. Cancers (Basel). 2023;15(7):1953. DOI: http://dx.doi.org/10.3390/cancers15071953

11. Fonseca ÁC, Horta BA, Ladeia DN, Ligório GT, De Mello GBL, Machado IZ, et al. Timoma micronodular com estroma linfóide: relato de caso. Braz J Hea Rev. 2023;6(4):17300-6. DOI: http://dx.doi.org/10.34119/bjhrv6n4-253

12. Wu ECF, Sit D, Derocher H, Lin A, Sauciuc D, Murchison SC, et al. A population-based study on the treatment and long-term outcomes of thymoma: A 25-year single institution retrospective review. Int J Radiat Oncol Biol Phys. 2022;114(3):e409-10. DOI: http://dx.doi.org/10.1016/j.ijrobp.2022.07.1588

Published

2026-08-09

How to Cite

1.
Leal Acosta A, Leal Mursulí A, Feliq Díaz Y, Anaya Mauri Y, Kessell Maura R. Micronodular Thymoma with Lymphoid Stroma. Rev. Cub. Cir. [Internet]. 2026 Aug. 9 [cited 2026 Oct. 14];65. Available from: https://revcirugia.sld.cu/index.php/cir/article/view/1758

Issue

Section

Presentaciones de casos