Current Controversies in Esophagogastric Anastomosis Following Esophagectomy

Authors

Keywords:

esophagectomy; esophagogastric anastomosis; anastomotic leak; esophageal surgery; critical review

Abstract

Introduction: Esophagogastric anastomosis following esophagectomy is a critical procedure that influences postoperative morbidity and mortality, with ongoing controversies regarding the site and technique of anastomosis, leak prevention, and complications.

Objective: To critically analyze the national and international literature on esophagogastric anastomosis by evaluating controversies related to the site, technique, and postoperative complications.

Methods: A review was conducted of articles published through September 2025 in international and Latin American databases. We included clinical trials, reviews, meta-analyses, and case series that evaluated the site and technique of anastomosis, the leakage rate, and complications.

Results: International evidence indicates that intrathoracic anastomosis carries a lower risk of leakage, while cervical anastomosis facilitates the management of complications. The manual technique is safe when basic surgical principles are followed. Cuban series show comparable results, with manageable cervical leaks and acceptable mortality. The incorporation of recovery protocols and minimally invasive surgery improves recovery and reduces complications.

Conclusions: The choice of anastomotic site and technique should be tailored to each individual case, taking into account international evidence, the surgical team’s experience, and local conditions. It is recommended to strengthen local documentation, promote multicenter studies, and progressively implement recovery protocols to optimize surgical outcomes in resource-limited settings.

Downloads

Download data is not yet available.

References

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-49. DOI: https://doi.org/10.3322/caac.21660

2. Low DE, Alderson D, Cecconello I, Chang AC, Darling GE, D’Journo XB, et al. International consensus on standardization of data collection for complications associated with esophagectomy (Esophagectomy Complications Consensus Group, ECCG). Ann Surg. 2015;262(2):286-94. DOI: https://doi.org/10.1097/SLA.0000000000001098

3. Markar SR, Gronnier C, Duhamel A, Mabrut JY, Bail JP, Carrere N, et al. The impact of severe anastomotic leak on long-term survival and cancer recurrence after surgical resection for esophageal malignancy. Ann Surg. 2015;262(6):972-80. DOI: https://doi.org/10.1097/SLA.0000000000001011

4. Van Workum F, Verstegen MHP, Klarenbeek BR, Bouwense SAW, van Berge Henegouwen MI, Daams F, et al. Intrathoracic vs Cervical Anastomosis After Totally or Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer: A Randomized Clinical Trial. JAMA Surg. 2021;156(7):601-10. DOI: https://doi.org/10.1001/jamasurg.2021.1555

5. You J, Zhang H, Li W, Dai N, Lu B, Ji Z, et al. Intrathoracic versus cervical anastomosis in esophagectomy for esophageal cancer: a meta-analysis of randomized controlled trials. Surgery. 2022;172(2):575-83. DOI: https://doi.org/10.1016/j.surg.2022.03.006

6. Gooszen JAH, Goense L, Gisbertz SS, Ruurda JP, van Hillegersberg R, van Berge Henegouwen MI. Intrathoracic vs cervical anastomosis and predictors of anastomotic leakage after oesophagectomy for cancer. Br J Surg. 2018;105(5):552-60. DOI: https://doi.org/10.1002/bjs.10728

7. Valverde A, Hay JM, Fingerhut A, Elhadad A. Manual versus mechanical esophagogastric anastomosis after resection for carcinoma: a controlled trial. French Associations for Surgical Research. Surgery. 1996;120(3):476-83. DOI: https://doi.org/10.1016/s0039-6060(96)80066-3

8. Castaño R, Salazar O, Piñeres AD, Jaramillo R, Molina S, Aristizábal F, et al. Comparación de la anastomosis cervical manual vs mecánica en una serie prospectiva de pacientes con esofagectomía por cáncer. Perú, Lima. Rev. Gastroenterol. 2021;41(2):65-72. DOI: https://dx.doi.org/10.47892/rgp.2021.412.1268

9. Sosa JG, Pérez K, Pérez J, Martínez A, Díaz JM. Esofagectomías como opción terapéutica en el cáncer esofágico. Rev Cub Cir. 2024 [acceso 08/04/2025];63:e1566. Disponible en: https://www.revcirugia.sld.cu/index.php/cir/article/view/1566

10. Columbié PA, Rodríguez Z, Cisneros CM, Falcón GC, Lubín A, Romero LI. Morbilidad y mortalidad de pacientes operados de cáncer de esófago. Rev Cub Cir. 2023 [acceso 08/04/2025];62(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-74932023000100009&lng=es

11. Nazario AM, Suárez JA, Romero LI, Falcón GC, Matos ME, Rodríguez Z. Complicaciones de la esofagectomía por cáncer de esófago. Rev Cub Cir. 2022 [acceso 08/04/2025];61(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-74932022000200003 &lng=es

Published

2026-08-08

How to Cite

1.
Pérez Garcia K, Pérez Palenzuela J, Sosa Martín JG. Current Controversies in Esophagogastric Anastomosis Following Esophagectomy. Rev. Cub. Cir. [Internet]. 2026 Aug. 8 [cited 2026 Aug. 9];65. Available from: https://revcirugia.sld.cu/index.php/cir/article/view/1804

Issue

Section

Artículos de revisión